2014 Publications

Befroy, D. E., Perry, R. J., Jain, N., Dufour, S., Cline, G. W., Trimmer, J. K., Brosnan, J., Rothman, D. L., Petersen, K. F., and Shulman, G. I. (2014) Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy, Nat Med 20, 98-102.

Cao, J., Perez, S. M., Goodwin, B., Lin, Q., Peng, H., Qadri, A., Zhou, Y., Clark, R. W., Perreault, M., Tobin, J. F., and Gimeno, R. E. (2014) Mice Deleted for GPAT3 Have Reduced GPAT Activity in White Adipose Tissue and Altered Energy and Cholesterol Homeostasis in Diet-induced Obesity, Am J Physiol Endocrinol Metab

Dullea, R., Salatto, C., Sciabola, S., Chen, T., Dimattia, D., Gandhok, H., Kreeger, J., Weng, Y., Clark, T., Vage, C., and Stanton, R. (2014) Study of CRTC2 Pharmacology Using Antisense Oligonuceotides, Nucleic Acid Ther 24, 127-138.

Flannick, J., Thorleifsson, G., Beer, N. L., Jacobs, S. B., Grarup, N., Burtt, N. P., Mahajan, A., Fuchsberger, C., Atzmon, G., Benediktsson, R., Blangero, J., Bowden, D. W., Brandslund, I., Brosnan, J., Burslem, F., Chambers, J., Cho, Y. S., Christensen, C., Douglas, D. A., Duggirala, R., Dymek, Z., Farjoun, Y., Fennell, T., Fontanillas, P., Forsen, T., Gabriel, S., Glaser, B., Gudbjartsson, D. F., Hanis, C., Hansen, T., Hreidarsson, A. B., Hveem, K., Ingelsson, E., Isomaa, B., Johansson, S., Jorgensen, T., Jorgensen, M. E., Kathiresan, S., Kong, A., Kooner, J., Kravic, J., Laakso, M., Lee, J. Y., Lind, L., Lindgren, C. M., Linneberg, A., Masson, G., Meitinger, T., Mohlke, K. L., Molven, A., Morris, A. P., Potluri, S., Rauramaa, R., Ribel-Madsen, R., Richard, A. M., Rolph, T., Salomaa, V., Segre, A. V., Skarstrand, H., Steinthorsdottir, V., Stringham, H. M., Sulem, P., Tai, E. S., Teo, Y. Y., Teslovich, T., Thorsteinsdottir, U., Trimmer, J. K., Tuomi, T., Tuomilehto, J., Vaziri-Sani, F., Voight, B. F., Wilson, J. G., Boehnke, M., McCarthy, M. I., Njolstad, P. R., Pedersen, O., Groop, L., Cox, D. R., Stefansson, K., and Altshuler, D. (2014) Loss-of-function mutations in SLC30A8 protect against type 2 diabetes, Nat Genet 46, 357-363.

Hall, A. M., Soufi, N., Chambers, K. T., Chen, Z., Schweitzer, G. G., McCommis, K. S., Erion, D. M., Graham, M. J., Su, X., and Finck, B. N. (2014) Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice, Diabetes

Kuc, R. E., Maguire, J. J., Siew, K., Patel, S., Derksen, D. R., Margaret Jackson, V., O'Shaughnessey, K. M., and Davenport, A. P. (2014) Characterization of [(125)I]GLP-1(9-36), a novel radiolabeled analog of the major metabolite of glucagon-like peptide 1 to a receptor distinct from GLP1-R and function of the peptide in murine aorta, Life Sci 102, 134-138.

Lee, D.V., Li, D., Yan, Q., Zhu, Y., Goodwin, B., et al. (2014) Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes, PLoS ONE 9(11): e111767. doi:10.1371/journal.pone.0111767

Lee, E. C., Tu, M., Stevens, B. D., Bian, J., Aspnes, G., Perreault, C., Sammons, M. F., Wright, S. W., Litchfield, J., Kalgutkar, A. S., Sharma, R., Didiuk, M. T., Ebner, D. C., Filipski, K. J., Brown, J., Atkinson, K., Pfefferkorn, J. A., and Guzman-Perez, A. (2014) Identification of a novel conformationally constrained glucagon receptor antagonist, Bioorg Med Chem Lett 24, 839-844.

McInnes, I. B., Kim, H. Y., Lee, S. H., Mandel, D., Song, Y. W., Connell, C. A., Luo, Z., Brosnan, M. J., Zuckerman, A., Zwillich, S. H., and Bradley, J. D. (2014) Open-label tofacitinib and double-blind atorvastatin in rheumatoid arthritis patients: a randomised study, Ann Rheum Dis 73, 124-131.

Pettersen, J. C., Litchfield, J., Neef, N., Schmidt, S. P., Shirai, N., Walters, K. M., Enerson, B. E., Chatman, L. A., and Pfefferkorn, J. A. (2014) The Relationship of Glucokinase Activator-induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies, Toxicol Pathol

Sharma, A., Huard, C., Vernochet, C., Ziemek, D., Knowlton, K. M., Tyminski, E., Paradis, T., Zhang, Y., Jones, J. E., von Schack, D., Brown, C. T., Milos, P. M., Coyle, A. J., Tremblay, F., and Martinez, R. V. (2014) Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6, PLoS One 9, e92608.

Shin, S.-Y., Fauman, E. B., Petersen, A.-K., Krumsiek, J., Santos, R., Huang, J., Arnold, M., Erte, I., Forgetta, V., Yang, T.-P., Walter, K., Menni, C., Chen, L., Vasquez, L., Valdes, A. M., Hyde, C. L., Wang, V., Ziemek, D., Roberts, P., Xi, L., Grundberg, E., Consortium, T. M. T. H. E. R. M., Waldenberger, M., Richards, J. B., Mohney, R. P., Milburn, M. V., John, S. L., Trimmer, J., Theis, F. J., Overington, J. P., Suhre, K., Brosnan, M. J., Gieger, C., Kastenmüller, G., Spector, T. D., and Nicole Soranzo, N. (2014) An atlas of genetic influences on human blood metabolites, Nat. Genet., In Press

Withka, J. M., Borzilleri, K., Pfefferkorn, J. A., Guzman-Perez, A., Liu, S., Qiu, X., Chrunyk, B., Song, X., Tu, M., Filipski, K., Aiello, R., Derksen, D., Bourbonais, F., Landro, J., Bourassa, P., D’Aquila, T., Baker, L., Barrucci, N., Litchfield, J., Atkinson, K., and Rolph, T. (2014) Optimizing Glucokinase Activator Binding Kinetics to Lower in vivo Hypoglycemia Risk, Med Chem. Comm. In Press

Bhattacharya, S. K., Andrews, K., Beveridge, R., K.O., C., Chen, J. C., Dunn, M., Fernando, D. P., Gao, H., Hepworth, D., Jackson, V. M., Khot, V., Kong, J., Kosa, R., Lapham, K., Loria, P., Londregan, A. P., McClure, K. F., Orr, S. T. M., Patel, J., Rose, C., Saenz, J., Stock, I. A., Storer, G., VanVolkenburg, M., Vrieze, D., Wang, G., Xiao, J., and Zhang, Y. (2014) Discovery of PF-5190457, a potent, selective and orally bioavailable GHS-R1a inverse agonist clinical candidate, ACS Med. Chem. Lett., In Press